| Day | Date | Opponent | Location | TV | Outcome/Time |
| Wed | 11/01/2000 | Branch West (Exh.) | San Diego | | L, 83-82
Recap | Stats |
| Wed | 11/08/2000 | LA Stars (Exh.) | San Diego | | W, 90-71
Recap | Stats |
| Sat | 11/18/2000 | UC San Diego | San Diego | | W, 80-48
Recap | Stats | Quotes | Notes |
| Tue | 11/21/2000 | New Mexico State | San Diego | | W, 77-62
Recap | Stats | Quotes | Notes | Archived Audio |
| Mon | 11/27/2000 | at Fresno State | Fresno, Calif. | | L, 70-62
Recap | Stats | Archived Audio |
| Thu | 11/30/2000 | Florida Atlantic | San Diego | | W, 90-57
Recap | Stats | Quotes | Notes | Archived Audio |
| Sat | 12/02/2000 | Cal St. Sacramento | San Diego | | W, 91-69
Recap | Stats | Quotes | Notes | Archived Audio |
| Wed | 12/06/2000 | at UC Santa Barbara | Santa Barbara, Calif. | | L, 80-77
Recap | Stats | Archived Audio |
| Sat | 12/09/2000 | San Diego | San Diego | | L, 55-52
Recap | Stats | Quotes | Notes | Archived Audio |
| Sat | 12/16/2000 | Arizona State | San Diego | Fox Sports-Arizona | W, 64-62
Recap | Stats | Quotes | Notes | Archived Audio |
| Thu | 12/21/2000 | Morgan State | San Diego | | W, 78-64
Recap | Stats | Quotes | Notes | Archived Audio |
| Thu | 12/28/2000 | Norfolk State | San Diego | | W, 79-69
Recap | Stats | Quotes | Notes | Archived Audio |
| Sat | 12/30/2000 | Oklahoma State | San Diego | | W, 87-66
Recap | Stats | Quotes | Notes | Archived Audio |
| Thu | 01/04/2001 | Texas A&M-Corpus Christi | San Diego | | W, 84-70
Recap | Stats | Quotes | Notes | Live Audio |
| Sat | 01/06/2001 | at Loyola Marymount | Los Angeles | | W, 61-58
Recap | Stats | Archived Audio |
| Mon | 01/08/2001 | New Mexico* | San Diego | SportsWest | L, 75-67
Recap | Stats | Quotes | Notes | Archived Audio |
| Sat | 01/13/2001 | at Brigham Young* | Provo, Utah | ESPN+Plus | L, 79-50
Recap | Stats | Archived Audio |
| Mon | 01/15/2001 | at Utah* | Salt Lake City | | L, 58-39
Recap | Stats | Archived Audio |
| Sat | 01/20/2001 | Air Force* | San Diego | SportsWest | W, 67-43
Recap | Stats | Archived Audio |
| Sat | 01/27/2001 | at UNLV* | Las Vegas | SportsWest | L, 82-72
Recap | Stats |
| Sat | 02/03/2001 | at Wyoming* | Laramie, Wyo. | SportsWest | L, 101-66
Recap | Stats | Quotes | Archived Audio |
| Mon | 02/05/2001 | at Colorado State* | Fort Collins, Colo. | | L, 77-56
Recap | Stats | Archived Audio |
| Sat | 02/10/2001 | Utah* | San Diego | Ch. 4-San Diego | L, 76-63
Recap | Stats | Quotes | Archived Audio |
| Mon | 02/12/2001 | Brigham Young* | San Diego | SportsWest | L, 69-66
Recap | Stats | Notes | Archived Audio |
| Sat | 02/17/2001 | at New Mexico* | Albuquerque, N.M. | ESPN+Plus | L, 72-54
Recap | Stats | Quotes | Archived Audio |
| Mon | 02/19/2001 | at Air Force* | Colorado Springs, Colo. | | W, 62-48
Recap | Stats | Notes | Archived Audio |
| Sat | 02/24/2001 | UNLV* | San Diego | SportsWest | W, 83-66
Recap | Stats | Quotes | Notes | Archived Audio |
| Thu | 03/01/2001 | Wyoming* | San Diego | | L, 69-62
Recap | Stats | Quotes | Notes | Archived Audio |
| Sat | 03/03/2001 | Colorado State* | San Diego | | W, 78-73
Recap | Stats | Quotes | Notes | Archived Audio |
| Thu | 03/08/2001 | Wyoming (Mountain West Tournament) | Las Vegas | ESPN/SportsWest | L, 73-58
Recap | Stats | Archived Audio | FANSlive GameTracker |
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